They must get some kind of monetary bonus for only selling Simparica. 8 months of prednisone and around the clock nursing care at home saved her life. How can you give a dog a pesticide to ingest. This is still going on weeks later. I just want to cry! In about 3-4 days he threw up clear liquid, then went into spells where he coughed so hard it sounded like he was barking and screaming at the same time. I will never give this again! I came across this site and read so much about symptoms that I now realize he has been having. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. I called the maker of Simparica and filed an FDA case for my dog and told them all of the symptoms she was having from this medicine. Does any one think this could be a reaction to Simparico Trio? Couple of days ago, I took my other doxie (Maddie) into my vet, for shots, he did the heart worm test and recommended Simparica. We tried stopping the simparica. It just dawned on me to look and see if this drug might be the reason. What are the side effects of simparica trio for dogs? So here we are on the 2nd dose. Simparica can't be used on younger dogs or lactating dogs whereas Revolution can. She has NEVER done that before. Our miniature schnauzer has been extremely thirsty and itchy to the point of biting until he bleeds. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. Shame on me for trusting the doctors that shrug off their responsibilities to the office girls for one thing. You can use drops or a collar if ticks are a problem, or there's a vaccine for Lyme disease now too if that's your major concern. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. When he lays in the sun you can see the bumps under his skin. I will have to keep an eye out on her. I lost my girl 2 days after taking Simparica. Gave my 14 month old 88 lb. Im certain that its the simparica. Simparica Trio Recall can be trusted with their product. My nearly 14 year old Havanese Kokomo has taken a sharp decline in the last 8 month and I was blaming it on old age when I think I may have been poisoning him. Today started diarrhea & he has gone 5 times so far while not eating much. Today, he wouldn't eat or drink any water. Later in the fall I noticed some leg tremors when she squatted. They drew blood & took a fecal sample . I disagree. I am keeping a close eye on her and will take her to the vet if she hasnt improved by tonight. My dog died from it after one dose within 24 hours. Two days later, she is doing better, but not 100% yet. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. The vet did a nasal lavage under anesthesia and got a lot of mucus. My wife and I didn't understand why. He has trouble raising his leg to urinate. She will not get this anymore. Then she lost control of her legs and couldn't walk or stand. He was a Shih Tzu. Our dog had her first dose June 1st 2022 - diarrhea, scratching, excessive thirst. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). Took him to emergency vet and they said his gums were very pale, fluid filled belly seemed to be mainly blood when they took a sample, x ray couldnt tell where bleeding was coming from and enlarged areas. Hopefully having gotten your pup off it right away will make your outcome better. It's 5:53pm and he's acting very lethargic. I hope it is better. He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. She is only 6 and was so full of life and energy. It's been the worst 2 months. Did you go to the vets or not? Nothing. Shame on you! Hopefully, there is no permanent damage to his brain or body. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog. Somedays he will have 2 and then he will go for a couple days without having any issues. This morning (12/19/21) was a bit better, still hesitant on the steps but we didnt experience any loss of appetite and was eager to go outside (still some diarrhea though). It's not worth the risk of additional seizures or other neurological effects, and it seems that his stumbling and getting tired sooner on walks are likely related. Normal. Vet did all kinds of tests but said it couldnt be simparica. Simparica only offers chewables. They had no clue what had happened so again we took him to the er and he checked out fine. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. She was being seen by her regular vet and was put on antibiotics. Please anyone let me know if there is a class action law suit or where we can start one? He's experiencing auto-inmune disease symptoms and we were told he is in critical condition. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). And both of my other labs, basically house dogs, ended up with a droopy left eye. The American Heartworm Society recommends year-round heartworm prevention for all dogs in the United States, and the Companion Animal Parasite Council recommends broad-spectrum parasite control to prevent heartworms, intestinal parasites, fleas, and ticks for all dogs in North America. He is starting to get better. The following day he died. Will be talking to the vet inregards to his side effects. I am so upset - I gave it to him last week and he had an accident in the house. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. She didn't make it to the next day and died overnight. Will not use this again and will warn others. Please think these things through before subjecting your pet to internal insecticides. Ive spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. this link is to an external site that may or may not meet accessibility guidelines. This medication is generally well tolerated in most pets. . Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . Hearing 35-40 to leave systems. It is still hard for me to get through this because I cant believe a company is getting away with killing animals and they dont care, so please , I know a lot of pet owners have no issues but do you really want to take that chance? It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. I gave my six-year-old dog SIM perica because the combo guard was on back order. Eat grass and vomit. Tell your veterinarian if your dog has a history of seizures or other neurologic disease. My 3 month old shih tux Juno took her second dose last week and for the last two days shes vomited and has been eating grass nonstop! He just couldn't stand good, he constantly shakes his head. I am very worried I called the vet they said oops sorry they made a mistake. Overly anxious. We took him to vet and they gave nausea meds and kept him overnight. I am worried! I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. Trifexis is much safer and I really don't care about the ticks - I can pull those off. It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. In our case the damage was permanent. To make dosing easy, it's available for dogs in six sizes based on body weight range: Simparica Trio can be given to dogs with or without food. If your dog or cat experiences any adverse event while using an isoxazoline product, first consult your veterinarian. Is it effective? After reading all of supporting reviews, I will never give him this again. If you accidentally ingest a pet medication, call your physician or the national Poison Control Center hotline at 800-222-1222. Does anybody know how long this will last? By the following day, she was showing symptoms of marked neurological impairment, similar to a human having suffered a stroke. The FDA is alerting pet owners and veterinarians of the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. Two months no flare up no more scabs and loosing hair. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hoursincluding the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. I not any kind of a medical doctor nor am I a vet however I do often research many topics on health related matters both canine and human for decades and then use my common sense to draw logical conclusions or make reasonable guesses. It causes paralysis that leads to death of hookworms and roundworms. I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Saturday he started up the drinking again and threw up his breakfast. Can someone please tell me if their dogs got better after taking the pill? She's not drinking water or eating all she wants to do is sleep. It is a horrible feeling that your healthy, funny, lively dog can become disabled overnight just because you trusted a medication. A week after I lost her I got COVID and was in the hospital for 20 days. Sorry man, that is horrible. So, I gave it to him. Took a dose of simparica trio.second rose in second month.dog is having tremors. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). All went well until this morning. She hasn't had any of the diarrhea or eating issues, but has had one of her eyes that gets red and the inner eyelid partially covers her pupil. Simparica Trio can be administered to your dog at any age, but it's best to start treating your dog one month before the fleas become active. The personality change is what has me most concerned too. My 18 month old dog has had Sim Perica trio. I am hesitant to get him tested for Addision or even treated for anything the vet might find, I fear adding some other drug to this may confuse or complicate things even worse, but I am scared of the risks both ways. I wish I had read these comments before giving this to my Frenchie. Thank you all so much!!!! Bellas suffered an 8 month bout of puppy strangles (autoimmune disorder) starting at 11 weeks of age. We contacted the company using the phone number supplied in the under in the box and shared our experience with the new drug. So you can imagine my worry now. He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. Some pets fare better with topical solutions instead of chewables. I don't recommend anyone risk their pet's life just to be a little easier having a pill to take. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. I finally got him to eat some chicken and he threw that up 2 hours later. She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. We hope this will solve our problems and he can live a healthy and happy life. My best friend's new puppy has had diarrhea for 14 days after taking one dose of Simparica. Not sure what effects he will continue to have. I'm just so angry that the vet prescribed this and I am mad at myself for not researching it. Please do not use this drug. He has been on simparica since he was old enough to take it. So, again, tears in my heart, THANK YOU ALL SO MUCH for your generous information. Side effects are uncommon, but may occur in some cases. I just cross my fingers every day that she will get better after this is out of her system. (145 Reviews) $15.50 - $31.09. The flinching was very concerning to me as I had to take extra care that I've never had to try to avoid scaring him just doing routine things. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. (My first warning sign right there). I give my dogs Simparica at the beginning of each month. Our new vet has recommended Simperica, but I wont be giving it to my Collie. Use topical or a collar if you are concerned. Two quick questionsDo the dogs eventually return to normal? He had ONE dose that evening and completely lost his appetite within a couple days. So your dog got better? The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. They gave him a strong shot of prednisone that was good for 2 days . This medication should be banned and the company held responsible. She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. Today the seizure like attack happened even though he is on the steroids. He is stumbling, not able to stand on tile or go in and out of house without tripping on steps. So bad that the FDA made them put a huge warning now on the package. I will not be continuing with this treatment. He has been very lethargic, he was an extremely playful pup. We are going back to the Seresto collar next month. She is lethargic and doesnt want to eat. Simparica Trio comes with a customer satisfaction guarantee: Zoetis will cover some or all vet expenses should your dog develop heartworm disease, Lyme disease, a flea infestation, hookworms, or roundworms. I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. He is eating fine with no diarrhea or vomiting. Started downhill health issues with initial dose. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. iI hope she will not have any other problems. We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. Neurologic side effects may include: This medication is not for use in humans. Final Thoughts on Trifexis vs Simparica. I am taking them both off Simparica. He licks his lips all the time? The company's thinking must be the profits outweigh the loses from any lawsuits lost its important to note that the law treats animals as property and the fix value of a dog is quite small and limited. After her first dose she had diarrhea, vomiting and developed a terrible wheezing hacking cough. How long did it last with your dog? Sarah thanks for your response! Very "out of it". only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. Same here! For: I gave my black lab mix Simparica for the 1st time on 4/1. I honestly think she had a reaction to the medication. The vet insisted it was not from the Simparica Trio. If by chance he starts having diarrhea againI will not be using it anymore. In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. A week ago I gave him Trifexis because he had been on it a few years ago.the next night he had a seizure. I took him in today and they think it might be meningitis. Side effects are uncommon, but may occur in some cases. . This happened the same to my dog.. how si going now with your pet? First month, the one threw up, same thing second month. Not even going to risk it . My vet seems skeptical that this is related to simparica but it seems clear to me, although I realize that anecdotal cases don't prove it. (Ours never did, she died 4 months later.) I do know that she was a healthy and somewhat energetic 10 year old before the treatment. Just a little nervous !! I gave my dog his first dose April 8th. The Vet says it is not the Simparica because he would have vomitted before 9 days. Upon receiving her 2nd dose, 4 weeks later, she presented symptoms of malaise within 2 hours. He is pissing a lot and often and drinking a lot of water. He took simparica trio 3 weeks ago and I cant wait until its out of his system! I am up writing this 4 a.m. since our Lambchop is too restless to sleep! I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. This is terrible. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. My personal dog has had no issues at all, and she's been on it for nearly two years. I lost my dog due to Simparica Trio. Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. Advised I could call Simparica for reimbursement or to report side effects. She's finally resting at home, but still not able to walk, run, eat, etc. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. I put water with electrolytes by his cage & food . Please advise! I am feeding her foods such as spirulina; b12 and a special healing earth in her dinner. Sometimes I think he is either blind or deaf. But the wandering and "head pressing" it's called, where they just go into the corner or lean against a table leg or the wall. Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. In addition to killing fleas and several kinds of ticks, Simparicais effective in preventing and treating mange and ear mites. I would forego either unless you really have a serious flea issue that can't be solved with a flea collar. I wish I would have seen this conversation before giving my 8 year old Labrador Retriever his first dose of Simparica Trio on Wednesday March 31st! the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. Most of us dog parents use some form of heartworm prevention for our dogs. Hi, how long it took for the diarrhea to go away. UPDATE We had one normal day on Friday. Thank you for this information. No side effects. Then suddenly dog has diarrhea and it lasted for several days. For all symptoms to be reversed & to return to normal . Is due for another tablet but I have been holding off. Simparica has possibly shown no severe side effects that may concern the health of dogs. I wouldnt have given it to her. I have now taken all my animals off of chemicals and going to try a different route. She falls when she runs and when going up and down stairs. Today was my 14 year old Jack Russell's 2nd dose of Simparica, her name is Rallye. Hope all is well. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. My dog (6 years old) has been using monthly Simparica since I got him. How is your dog doing? Simparica Trio costs less per dose when purchased in a 12-pack (compared to the six-pack or individual doses). This is worth the cost to buy a six-pack of protection. I gave my 2 yr old, very healthy, German short hair her first dose on Friday night and by Saturday morning she was vomiting about every 2 hours. She had what seemed like a seizure 6 hours after ingesting this product--she was lying in her crate, she peed while lying down, and she vomited, then began rocking back and forth--and now I am terrified for her (it's Saturday, nearly midnight, so tomorrow is Sunday and everything is closed). My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. You ask why they are giving this poison to our furbabies, it's easy. Did you ever do an MRI or spinal tap? He loves the taste of Simparica Trio and it's like a treat for him. oh I should mention shadow is our 8 yr old dogue de Bordeaux - he has never had a reaction to anything ever before in his life and has never needed a vet so this was not usual at all for him .. My beautiful Golden was switched from her previous Medicine to this one. I keep praying she will recover and I feel so guilty for giving it to her. These include vomiting, diarrhea, lethargy, inappetence, itching, and, very . Is there any good outcomes from this tablet? I'm so sorry. He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. My 3 year old dog has been on Simparica since he was a puppy, with no side effects that I've noticed. Im wondering if after it is out of his system or have I now poisoned my baby where he might have a seizure disorder for the rest of his life. I am so worried after reading these comments. I have an appointment this Wednesday but not sure if Im going to keep it if the cough will go away eventually. By the evening she lost the use of her hind legs. And since then has had diarrhea and loose poop. Made the pressured in to by a vet to give Simparica Trio. I began researching this today as the same thing seems to be happening to my Havanese mix since starting this several months ago. It has been five days and the diarrhea started on day 2. This medication must really be strong to do Flea tic and heart worm etc. My 1 year old Italian Spinone puppy has been losing hair on her back and has a big ear infection. How did your baby do please? Always confirm storage temperatures by reading the label. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. Previously B was on Heartgard and Advantix worked well I guess we switch back. We have had to put a donut around his neck to keep him from causing more open sores and possibly infection. My sincere sympathies to those with horrendous seizure side effects. The representative for the company says the half life is 16 days. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. He scratched at them which made it worse. I am so worried about her I called to explain and was told to feed her chicken and rice and if she isn't improved take her to Emergency Vet Hospital. Use a collar or topical if you need to. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. Lost all appetite. Kind of ooze. I've tried Gatorade and Ginger ale but he only drank a little. They kindly asked that we schedule an immediate check and diagnostic testing at our local vet. All content contained in this article is sourced from public sources or the manufacturer. The leaflet inside at least needs to be changed to have the correct information on it. I'll be spreading the word. I'm totally stopping the drug, but, unfortunately, can't get in to my vet for almost a month to get a replacement. It all depends, sadly. I am so sorry for your loss. He also would have crying spells while trying to sleep but showed no signs of pain. I have always used topical tx. Times and is now seizing mainly her head or special care for generous... Answer any questions related to side effects that may concern the health dogs! 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